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What is HER2-positive breast cancer?
The Human Epidermal Growth Factor Receptor 2 (HER2) protein exists in breast cells to facilitate normal growth. In HER2-positive breast cancer, the HER2 protein is produced in excess, leading to tumour growth.(1)
This is an aggressive form of breast cancer that makes up 20% of all breast cancers. If left untreated, it is associated with quicker disease progression and poorer chances of survival compared to HER2-negative breast cancers.(2)
Treatment Journey
In the treatment of HER2-positive breast cancer, HER2 receptors(3) are targeted so as to block the signals causing cancer cells to grow and multiply.
References:
(1) Breastcancer.org. HER2 status. 2020. Available at https://www.breastcancer.org/symptoms/diagnosis/her2 [Accessed May 2021]
(2) Wolff AC, et al. Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update. J Clin Oncol. 2013;31:3997–4013.
(3) American Cancer Society. Targeted drug therapy for breast cancer. 2021. Available at https://www.cancer.org/cancer/breast-cancer/treatment/targeted-therapy-for-breast-cancer.html [Accessed May 2021]